The HNF4A Polyclonal Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to HNF4, HNF4A, HNF4a7, HNF4alpha, and TCF. This antibody recognizes Human, Mouse, and Rat antigen. The HNF4A Polyclonal Antibody has been validated for the following applications: Immunofluorescence, Immunohistochemistry, and Western Blot.
Description
Hepatocyte nuclear factor 4alpha (HNF4alpha) is a transcription factor that belongs to the steroid hormone receptor superfamily and is enriched in liver (1). HNF4alpha, in association with PGC-1alpha, activates gluconeogenic genes such as phosphoenolpyruvate carboxykinase and glucose-6-phosphatase genes in fasted livers (2,3). Conditional knockout of the HNF4alpha gene in the mouse liver destroys lipid homeostasis and leads to lipid accumulation in the liver and a reduction of serum cholesterol and triglyceride levels (4). Mutations in HNF4alpha have been linked to maturity-onset diabetes of the young (MODY) (5)